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If ingestion is well absorbed from the gastrointestinal tract. Simultaneous food intake does not affect absorption. Repeated ingestion of doses 7,5 — 15 mg, plasma concentrations are proportional to dose. The equilibrium concentrations are reached within 3 — 5 Buy. Plasma protein binding mostly to albumin is about 99. The value associated with protein fractions do not depend on the concentration in the therapeutic dose range.

The volume of distribution of meloxicam in average 10 liters. It penetrates generic the blood-tissue barriers. Almost completely metabolized in the liver with the formation of four pharmacologically inactive derivatives. Studies in vitro showed that the metabolic conversion of the important role played by CYP2C9. Derived equally from feces and urine, mainly as metabolites. In the urine in unchanged form is found only in trace amounts. In hepatic and renal insufficiency of moderate severity significant changes pharmacokinetic parameters were observed.

Meloxicam showed no mutagennocti in the Ames test, did not reveal clastogenic in chromosome aberration test in cultured human lymphocytes cells and in the micronucleus test in bone marrow of mice in vivo. Buy of the substance Meloxicam Inflammatory and degenerative diseases of the joints accompanied by pain: Restrictions on the use Erosive — ulcerative lesions of the gastrointestinal tract in the history of elderly patients.

Application of pregnancy and breastfeeding Teratogenic effects.

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Meloxicam passes through the placental barrier. Adequate and well-controlled studies in pregnant women have not performed.

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Category effects on the fetus by FDA ; C. It can affect fertility, so it is not recommended for women wishing to become pregnant. Meloxicam excreted into the milk of lactating rats, while milk concentration exceeding the concentration in plasma. It is Buy known whether the meloxicam Online the breast milk of women penetrate, Meloxicam Generic Online Buy, so you should stop breast-feeding during treatment or avoid the use of meloxicam during the breastfeeding period. Side effects of substance Meloxicam From the digestive tract: From the nervous system and sensory organs: From the cardio — vascular system and blood blood, hemostasis: From the generic system: With the genitourinary system: Interaction In an application with acetylsalicylic acid and other NSAIDs increases the risk of erosive — ulcerative Meloxicam and bleeding from the gastrointestinal tract.

In an application with antihypertensive agents may decrease the effectiveness of the latter. In an application with lithium preparations possible accumulation of lithium and increase its toxic effect recommended monitoring the concentration of lithium in the blood. Concomitant use with methotrexate enhances side effects of the latter on the hematopoietic system there is a risk of anemia and leukopenia. A periodic blood count control.

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The dose is adjusted individually, you should use the lowest effective dose for the shortest period of time. Inside, during a meal, without chewing, in a dose of 7,5 — 15 mg Buy generic per day. Rectal ; one candle 15 mg per day. Online

The maximum daily dose of ; 15 Online in patients with Buy renal impairment on hemodialysis ; 7. The starting dose in patients with an Meloxicam risk of side effects ; 7. The appearance of gastroduodenal ulcers, gastrointestinal bleeding. The risk of gastro — intestinal complications Serious side effects from the generic tract.

A higher risk of serious complications from the gastrointestinal tract are elderly patients, the probability of occurrence of these complications increases as long-term use. The appointment of NSAIDs in patients with reduced renal blood flow and bcc can accelerate renal decompensation after discontinuation of NSAID kidney function is usually restored to Online previous level, Meloxicam Generic Online Buy. Particularly high risk of developing these reactions in with symptoms of Buy dehydration, congestive heart failure, liver cirrhosis, nephrotic syndrome, and generic renal disease, patients receiving diuretics and have undergone a significant surgical intervention, which led to hypovolemia from the beginning of treatment should be closely monitored urine output and renal function.

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