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If ingestion is well absorbed from the gastrointestinal tract. Simultaneous food intake does not affect absorption. Repeated ingestion of doses 7,5 — 15 mg, plasma concentrations are proportional to dose. The equilibrium concentrations are reached within 3 — 5 Buy. Plasma protein binding mostly to albumin is about 99. The value associated with protein fractions do not depend on the concentration in the therapeutic dose range.
The volume of distribution of meloxicam in average 10 liters. It penetrates generic the blood-tissue barriers. Almost completely metabolized in the liver with the formation of four pharmacologically inactive derivatives. Studies in vitro showed that the metabolic conversion of the important role played by CYP2C9. Derived equally from feces and urine, mainly as metabolites. In the urine in unchanged form is found only in trace amounts. In hepatic and renal insufficiency of moderate severity significant changes pharmacokinetic parameters were observed.
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Meloxicam passes through the placental barrier. Adequate and well-controlled studies in pregnant women have not performed.
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In an application with antihypertensive agents may decrease the effectiveness of the latter. In an application with lithium preparations possible accumulation of lithium and increase its toxic effect recommended monitoring the concentration of lithium in the blood. Concomitant use with methotrexate enhances side effects of the latter on the hematopoietic system there is a risk of anemia and leukopenia. A periodic blood count control.
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The maximum daily dose of ; 15 Online in patients with Buy renal impairment on hemodialysis ; 7. The starting dose in patients with an Meloxicam risk of side effects ; 7. The appearance of gastroduodenal ulcers, gastrointestinal bleeding. The risk of gastro — intestinal complications Serious side effects from the generic tract.
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